Pacemaker migration and sinus node arrest with methoxyflurane and halothane

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Pacemaker channel dysfunction in a patient with sinus node disease.

The cardiac pacemaker current I(f) is a major determinant of diastolic depolarization in sinus nodal cells and has a key role in heartbeat generation. Therefore, we hypothesized that some forms of "idiopathic" sinus node dysfunction (SND) are related to inherited dysfunctions of cardiac pacemaker ion channels. In a candidate gene approach, a heterozygous 1-bp deletion (1631delC) in exon 5 of th...

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Respiratory and Metabolic Changes during Methoxyflurane and Halothane Anaesthesia.

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Oxalic acid excretion after methoxyflurane and halothane anaesthesia.

METttOXYFLURANE IS A general anaesthetic that has been implicated in the production of postoperative renal dysfunction. 1-6 The precise mechanism is unknown, but the finding of many oxalate crystals in the renal tubules, 5,6 and large amounts of oxalic acid in the urine of patients who develop renal failure after methoxyflurane anaesthesia s has suggested the possibility that oxalic acid may be...

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Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture.

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ژورنال

عنوان ژورنال: Canadian Anaesthetists’ Society Journal

سال: 1971

ISSN: 0008-2856,1496-8975

DOI: 10.1007/bf03025442